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HIV-Associated Neurocognitive Disorder (HAND)
Our guest authors are Justin McArthur, MBBS, MPH, FAAN, Professor of Medicine, Neurology, Medicine, Epidemiology and Pathology, and Bryan Smith, MD, Department of Neurology Fellow at the Johns Hopkins University School of Medicine in Baltimore.

After participating in this activity, the participant will demonstrate the ability to:

Describe the clinical presentation, diagnosis, and appropriate management of HIV-associated neurocognitive disorder
Explain the differential diagnosis of cognitive symptoms for HIV-positive patients at different ages
Discuss the more complicated aspects of HAND and how treatments can be individualized depending on the varied mechanisms of HAND development, including IRIS

This discussion, offered as a downloadable audio file and companion transcript, covers the important issues related to HIV-Associated Neurocognitive Disorder (HAND), in the format of case-study scenarios, for the clinical practice. This program is a follow up to the Volume 1, Issue 7 eHIV Review newsletter HIV-Associated Neurocognitive Disorder (HAND)..


Unlabeled/Unapproved Uses
The presentation today will include discussion of the off-label use of memantine for the treatment of HAND.
Justin McArthur  Justin McArthur, MBBS, MPH, FAAN
Professor of Neurology, Medicine, Epidemiology and Pathology
Director, Department of Neurology
Neurologist in Chief
The Johns Hopkins University School of Medicine
Baltimore, Maryland
Bryan Smith  Bryan Smith, MD
Fellow, Division of Neuroimmunology and Neurological Infections
The Johns Hopkins University School of Medicine
Baltimore, Maryland

Faculty Disclosure
The authors have indicated that they have no financial interests or relationships with a commercial entity whose products or services are relevant to the content of this presentation.

Release Date
January 15, 2013
Expiration Date
January 14, 2014
Richard Moore, MD, MHS
Professor of Medicine
Director, Moore Clinic for HIV Care
Divisions of Infectious Diseases and
Clinical Pharmacology
The Johns Hopkins University School of Medicine
Baltimore, Maryland
Michael Melia, MD
Assistant Professor of Medicine
Associate Fellowship Program Director
Division of Infectious Diseases
The Johns Hopkins University School of Medicine
Baltimore, Maryland
 Accreditation Statements
The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designations
eNewsletter:The Johns Hopkins University School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)�. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Podcast:The Johns Hopkins University School of Medicine designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit(s)�. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful Completion
To successfully complete this activity, participants must read the content, then link to The Johns Hopkins University School of Medicine's website to complete the post-test and evaluation. Once you receive a passing grade, you can access and print your certificate of credit.

NOTE: If you already have registered for other Hopkins CME courses on the OCME website, simply enter the requested information when prompted.

There are no fees or prerequisites for this activity.

This activity is supported by educational grants from Abbott Laboratories, Boehringer Ingelheim Pharmaceuticals, Inc., and Bristol-Myers Squibb.

Launch Date
June 20, 2012; activities expire 1 year from the date of publication.

Intended Audience
This activity has been developed for infectious disease specialists, primary care physicians, nurse practitioners, and other health care practitioners whose work/practice includes treating HIV patients.

Faculty Disclosure
As a provider accredited by the Accreditation Council for Continuing Medical Education (ACCME), The Johns Hopkins University School of Medicine Office of Continuing Medical (OCME) requires signed disclosure of the existence of any financial relationships with industry from any individual in a position to control content of a CME activity sponsored by OCME. Members of the Planning Committee are required to disclose all relationships, regardless of their relevance to the activity content. Faculty are required to disclose only those relationships that are relevant to their specific presentations. The following relationships have been reported for this activity:

Richard Moore, MD, MHS has disclosed he has received grants/research support from Pfizer and GlaxoSmithKline. He has also served as a consultant for Bristol Myers-Squibb.

No other planners have indicated that they have any financial interests or relationships with a commercial entity.

Internet CME Policy
The Office of Continuing Medical Education (CME) at The Johns Hopkins University School of Medicine is committed to protecting the privacy of its members and customers. The Johns Hopkins University School of Medicine maintains its Internet site as an information resource and service for physicians, other health professionals, and the public.

Continuing Medical Education at The Johns Hopkins University School of Medicine will keep your personal and credit information confidential when you participate in an Internet-based CME program. Your information will never be given to anyone outside of the Johns Hopkins University School of Medicine program. CME collects only the information necessary to provide you with the services that you request.


Disclaimer Statement
The opinions and recommendations expressed by faculty and other experts whose input is included in this program are their own. This enduring material is produced for educational purposes only. Use of The Johns Hopkins University School of Medicine name implies review of educational format design and approach. Please review the complete prescribing information for specific drugs or combinations of drugs, including indications, contraindications, warnings, and adverse effects before administering pharmacologic therapy to patients.

Statement of Responsibility
The Johns Hopkins University School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity.

STATEMENT OF NEED:
Three central ideas emerged from our needs assessment. In order to provide optimal treatment to patients with HIV.

Clinicians caring for patients with HIV need current information about: appropriate treatment and maintenance of care�guidance for treating comorbidities�and information about emerging findings for treating HIV-associated neurocognitive disorders (HAND)
The need for more information on HIV topics including updated guidelines for HIV, treating older patients with HIV, managing patients with comorbidities and coinfections, treatment and sequencing �strategies for maximizing� future therapeutic options, and new and emerging agents for HIV
Treating comorbidities in patients with HIV, especially among people older than age 50

Confidentiality Disclaimer for Attendees

I certify that I am attending a Johns Hopkins University School of Medicine CME activity for accredited training and/or educational purposes.

I understand that while I am attending in this capacity, I may be exposed to "protected health information," as that term is defined and used in Hopkins policies and in the federal HIPAA privacy regulations (the Privacy Regulations). Protected health information is information about a person's health or treatment that identifies the person.

I pledge and agree to use and disclose any of this protected health information only for the training and/or educational purposes of my visit and to keep the information confidential.

I understand that I may direct to the Johns Hopkins Privacy Officer any questions I have about my obligations under this Confidentiality Pledge or under any of the Hopkins policies and procedures and applicable laws and regulations related to confidentiality. The contact information is Johns Hopkins Privacy Officer, telephone: 410�735�6509, e�mail: HIPAA@jhmi.edu.

"The Office of Continuing Medical Education at The Johns Hopkins University School of Medicine, as provider of this activity, has relayed information with the CME attendees/participants and certifies that the visitor is attending for training, education and/or observation purposes only."

For CME Questions, please contact the CME Office at (410) 955�2959 or e�mail cmenet@jhmi.edu.

For CME Certificates, please call (410) 502�9634.

Johns Hopkins University School of Medicine
Office of Continuing Medical Education
Turner 20/720 Rutland Avenue
Baltimore, Maryland 21205�2195

Reviewed and Approved by
General Counsel, Johns Hopkins Medicine (4/1/03)
Updated 4/09

Hardware & Software Requirements
Pentium 800 processor or greater, Windows 98/NT/2000/XP/7 or Mac OS 9/X, Microsoft Internet Explorer 5.5 or later, 56K or better modem, Windows Media Player 9.0 or later, 128 MB of RAM, sound card and speakers, Adobe Acrobat Reader, storage, Internet connectivity, and minimum connection speed. Monitor settings: High color at 800 x 600 pixels.
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